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L-Biome (Intestinal Health)

Gut Health
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Suggestions for use

DIRECTIONS: For adults, take two (2) capsules daily, preferably with a meal.



The L-Biome could be used daily by anyone aged 18-80. Best use is to take after doing one of ProLon’s Fasting Nutrition Products: 5 Days Fasting Mimicking Diet, One Day Reset Nutrition, Fast Bar or Fasting Shake. You can stop and restart at any time of your liking. If you have a health condition, consult with your doctor before taking the L-Biome. Do not take the L-Biome if you have allergies to any of its ingredients.
Supplements Facts Information

ProLon L-Biome

Average Contents for 2 capsule for 3 capsule
LACTOBACILLUS RHAMNOSUS HN001 18 mld CFU bn 27 mld CFU bn
BIFIDOBACTERIUM BREVE 10 mld CFU bn 15 mld CFU bn
SALT OF OMEGA-3-LYSINE FATTY ACIDS
of which DHA dodecohexanoic acid
of which L-lysine		 400 mg
200 mg
132 mg		 600 mg
300 mg
198 mg
INULINA / INULINE / INULIN 300 mg 450 mg

The package contains 60 capsules Weight: 37.8g

General information: L-BIOME is a dietary supplement containing probio- tics, prebiotics, DHA, and L-lysine that facilitates the balance of the intestinal bacterial flora. L-BIOME is well-tolerated as it is gluten and lactose-free. Lacto- bacillus rhamnosus HN001 and Bifidobacterium Breve B3 contribute to the re-establishment of the intestinal bacterial flora, by supporting the gut-im- mune system and favoring metabolism. Inulin contributes to providing the nourishment for probio- tic strains. DHA and lysine promote the integrity and proper functioning of tissues, including the intestinal one.

Intestinal bacterial flora is present in the lumen of the intestinal mucosa and is composed of microorganisms that protect the intestine from pathogenic germs, hinder infections, promote food digestion, regulate intestinal function, produce essential vitamins for the body, and eliminate harmful waste. The bacterial flora can be altered by various factors such as stress, a poor diet, and antibiotics. Prebiotics are the nourishment for the bacterial flora, promoting its growth. They are indigestible by the human intestine, and naturally found in many plant-based foods.

To carry out its beneficial action, the probiotic requi- res prebiotics intake. L-Biome is a synergistic blend of probiotics, prebiotics, DHA, and lysine to help promote intestinal well-being.

Ingredients: salt of omega-3 lysine fatty acids (Omega-3 from oil derived from the microalgae Schyzochitrium sp., L-lysine), L-Inulin; capsule: Hydroxypropyl methylcellu- lose; Bifidobacterium breve B3; anti-caking agent: Calcium biphosphate; Lactobacillus rhamnosus HN001; anti-caking agents: Magnesium salts of fatty acids,Talc; Calcium carbonate.

Dosage: Directions for use: It is recommended to take 2-3 capsules per day with a glass of water.

Storage Instructions: Store in a cool, dry place at a temperature not exceeding 25°C, away from light and/or heat sources.The minimum expiry date refers to the product if correctly stored in an intact package. Do not throw away in the environment after use.

WARNINGS: Directions for use: It is recommended to take 2-3 capsules per day with a glass of water.

Dietary supplements should not be considered as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. KEEP OUT OF REACH OF CHILDREN UNDER THREE YEARS OLD. Do not take in case of allergies or hypersensitivity to one or more components.

Download the Supplements Facts Information

Gut health is essential to a vibrant life. L-Biome will support your journey star
HOW TO USE

L-BIOME for optimal intestinal health

The probiotic strains Bifidobacterium Breve B3 and Lactobacillus Rhamnosus HN001 showed beneficial effects on improving life expectancy and alleviating age-related disorders by regulating the composition of the intestinal microbiota.

Bifidobacterium breve B-3

Clinical tests have shown that taking B. breve B-3 reduced the fat mass of adult subjects with a tendency to obesity. A possible improvement in the systemic inflammatory response was observed with the administration of B. breve B-3.

Lactobacillus Rhamnosus Hn001

This probiotic is particularly resistant to the action of bile. Thanks to this functionality, it is able to colonize the upper part of the small intestine and the colon. Numerous studies show that L.rhamnosus HN001 has a beneficial impact on intestinal barrier function.

Inulin

It is an insoluble fiber. Although processed foods provide taste and energy, they are deficient in fiber and their long-term consumption can lead to various disorders. Several studies show that inulin acts as a prebiotic and can promote the growth of Bifidobacteria and Lactobacillus species in the intestinal tract, thereby promoting a healthy digestive system

DHA

is an essential omega-3 polyunsaturated fatty acid, which is part of the composition of phospholipids in various organs, including the heart, brain and retina. DHA intake contributes to the maintenance of physiological brain function and normal visual capacity. Studies show that European populations consume few foods containing DHA, which creates deficiency situations that can be remedied by supplementation

Lysine

It is an essential amino acid for humans, which must therefore be supplied through food. Lysine plays several roles in humans, mainly in proteinogenesis, but also in the cross-linking of collagen polypeptides.

Feature Image 1

Innovation meets nature.

It is an essential amino acid for humans, which must therefore be supplied through food. Lysine plays several roles in humans, mainly in proteinogenesis, but also in the cross-linking of collagen polypeptides

Feature Image 1

Innovation meets nature.

L-Biome can be used daily by anyone aged 18 to 80. The best use is to take it after consuming one of the ProLon products: 5-day fasting mimicking diet, 1-day ReSet nutrition, Fast Bar nutritional program or the Fasting shake. You can stop and start again at any time. If you have any health problems, consult your doctor before taking L-Biome. Do not take L-Biome if you are allergic to any of its ingredients.

With L-Biome from ProLon, you don’t choose just a supplement, but a partner in your journey to longevity and healthy aging. While continually seeking to advance our understanding of longevity, we are committed to providing you with the best that science and nature have to offer today.

Selected references

Bifidumbacterium breve B-3:

  • Minami, J.I., Kondo, S., Yanagisawa, N., et al., 2015. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. Journal of Nutritional Science, 4.
  • Minami, J., Iwabuchi, N., Tanaka, M., et al., 2018. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Bioscience of Microbiota, Food and Health, pp.18-001.
  • Inoue T, Kobayashi Y, Mori N, Sakagawa M, et al., 2018. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. Benef Microbes. 2018 Dec 7;9.

 Lactobacillus rhamnosus HN001:

  • González-Hernández LA, Jave-Suarez LF, Fafutis-Morris M, Montes-Salcedo KE, Valle-Gutierrez LG, Campos-Loza AE, Enciso-Gómez LF, Andrade-Villanueva JF (2012) Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: a double-blind randomized controlled pilot trial. Nutr J 11:90.
  • Mokkala K, Pussinen P, Houttu N, Koivuniemi E, Vahlberg T, Laitinen K. (2018) The impact of probiotics and n-3 long-chain polyunsaturated fatty acids on intestinal permeability inpregnancy: a randomised clinical trial. Beneficial Microbes 9(2): 199-208
  • Kruger MC, Fear A, Chua WH, Plimmer GG, Schollum LM (2009) The effect of Lactobacillus rhamnosus on mineral absorption and bone health in growing male and ovariectomised female rats. Dairy Science & Technology 89:219-231.
  • Tannock GW, Taylor C, Lawley B, Loach D, Gould M, Dunn AC, McLellan AD, Black MA, McNoe L, Dekker J, Gopal P, Collett MA (2014) Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001. Applied and Environmental Microbiology 80:2851-2859
  • Miller LE, Ouwehand AC (2013) Probiotic supplementation decreases intestinal transit time: Meta- HN019, analysis of randomized controlled trials. World Journal of Gastroenterology 19:4718-4725

Inulin:

  • Shah BR, Li B, Al Sabbah H, Xu W, Mráz J. Effects of prebiotic dietary fibers and probiotics on human health: With special focus on recent advancement in their encapsulated formulations. Trends Food Sci Technol. 2020 Aug;102:178-192.
  • den Besten G., van Eunen K., Groen A.K., Venema K., Reijngoud D.-J., Bakker B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. 2013;54(9):2325–2340.
  • Dewulf E., Cani P., Claus S., Neyrinck A., Puylaert P., Glenn G.…Delzenne N. INULIN-TYPE fructans with prebiotic properties lessen endotoxemia and modulate host metabolism by changing gut microbiota composition in obese women: 749 accepted poster. Obesity Facts. 2012;5:200–201.
  • Dewulf E.M., Cani P.D., Neyrinck A.M., Possemiers S., Van Holle A., Muccioli G.G.…Sohet F.M. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry. 2011;22(8):712–722.
  • Nicolucci A.C. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology. 2017;153(3):711–722

Algal Oil DHA:

  • Jayapala H, Lim SY. N-3 Polyunsaturated Fatty Acids and Gut Microbiota. Comb Chem High Throughput Screen. 2022 Jul 1. doi: https://pubmed.ncbi.nlm.nih.gov/35786331/
  • Rousseau G. Microbiota, a New Playground for the Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Diseases. Mar Drugs. 2021 Jan 23;19(2):54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931107/
  • Stillwell W, Wassall SR. Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids. 2003;126(1):1-27.
  • Serhan CN. Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology. Nature. 2014 Jun 5; 510(7503): 92–101.
  • Kotani S, Sakaguchi E, Warashina S, et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 2006;56(2):159-64.
  • Innes JK, Calder PC. Marine Omega-3 (N-3) Fatty Acids for Cardiovascular Health: An Update for 2020. Int J Mol Sci. 2020 Feb 18;21(4):1362.
  • SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res. 2005;24(1):87-138

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